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专家解释究竟什么叫K线

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

Impaired mitochondrial maintenance in disparate cell types is a shared hallmark of many human pathologies and ageing. How mitochondrial biogenesis coordinates with the removal of damaged or superfluous mitochondria to maintain cellular homeostasis is not well understood. Here we show that mitophagy, a selective type of autophagy targeting mitochondria for degradation, interfaces with mitochondrial biogenesis to regulate mitochondrial content and longevity in Caenorhabditis elegans. We find that DCT-1 is a key mediator of mitophagy and longevity assurance under conditions of stress in C. elegans. Impairment of mitophagy compromises stress resistance and triggers mitochondrial retrograde signalling 专家解释究竟什么叫K线 through the SKN-1 transcription factor that regulates both mitochondrial biogenesis genes and mitophagy by enhancing DCT-1 expression. Our findings reveal a homeostatic feedback loop that integrates metabolic signals to coordinate the biogenesis and turnover of mitochondria. Uncoupling of these two processes during ageing contributes to overproliferation of damaged mitochondria and decline of cellular function.

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Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, Becker KG. Fang EF, et al. Sci Rep. 2017 Apr 11;7:46208. doi: 10.1038/srep46208. Sci Rep. 2017. PMID: 28397803 Free PMC article.

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Yan Y, Tang J, Yuan Q, Liu C, Chen X, Liu H, Huang J, Bao C, Hsiang T, Zheng L. Yan Y, et al. Commun Biol. 2022 Jul 14;5(1):698. doi: 10.1038/s42003-022-03666-5. Commun Biol. 2022. PMID: 35835849 Free PMC article.

Naranjo-Galindo FJ, Ai R, Fang EF, 专家解释究竟什么叫K线 Nilsen HL, SenGupta T. Naranjo-Galindo FJ, et al. Front Aging. 2022 Jun 22;3:916118. doi: 10.3389/fragi.2022.916118. eCollection 2022. Front Aging. 2022. PMID: 35821838 Free PMC article. Review.

Vega M, Castillo D, de Cubas L, Wang Y, Huang Y, Hidalgo E, Cabrera M. Vega M, et al. BMC Biol. 2022 Jul 12;20(1):160. doi: 10.1186/s12915-022-01352-w. BMC Biol. 2022. PMID: 35820914 Free PMC article.

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

Impaired mitochondrial maintenance in disparate cell types is a shared hallmark of many human pathologies and ageing. How mitochondrial biogenesis coordinates with the removal of damaged or superfluous mitochondria to maintain cellular homeostasis is not well understood. Here we show that 专家解释究竟什么叫K线 mitophagy, a selective type of autophagy targeting mitochondria for degradation, interfaces with mitochondrial biogenesis to regulate mitochondrial content and longevity in Caenorhabditis elegans. We find that DCT-1 is a key mediator of mitophagy and longevity assurance under conditions of stress in C. elegans. Impairment of mitophagy compromises stress resistance and triggers mitochondrial retrograde signalling through the SKN-1 transcription factor that regulates both mitochondrial biogenesis genes and mitophagy by enhancing DCT-1 expression. Our findings reveal a homeostatic feedback loop that integrates metabolic signals to coordinate the biogenesis and turnover of mitochondria. Uncoupling of these two 专家解释究竟什么叫K线 processes during ageing contributes to overproliferation of damaged mitochondria and decline of cellular function.

Similar articles

Palikaras K, Lionaki E, Tavernarakis N. Palikaras K, et al. Autophagy. 2015;11(8):1428-30. doi: 10.1080/15548627.2015.1061172. Autophagy. 2015. PMID: 26083448 Free PMC article.

Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson EM, Wollman BN, Marosi K, Wilson MA, Iser WB, Eckley DM, Zhang Y, Lehrmann E, Goldberg IG, Scheibye-Knudsen M, Mattson MP, Nilsen H, Bohr VA, 专家解释究竟什么叫K线 Becker KG. Fang EF, et al. Sci Rep. 2017 Apr 11;7:46208. doi: 专家解释究竟什么叫K线 10.1038/srep46208. Sci Rep. 2017. PMID: 28397803 Free PMC article.

Princz A, Pelisch F, Tavernarakis N. Princz A, et al. Sci Rep. 2020 Sep 23;10(1):15513. doi: 10.1038/s41598-020-72637-9. Sci Rep. 2020. PMID: 32968203 Free PMC article.

Palikaras K, Tavernarakis N. Palikaras K, et al. Exp Gerontol. 2014 Aug;56:182-8. doi: 专家解释究竟什么叫K线 10.1016/j.exger.2014.01.021. Epub 2014 Jan 28. Exp Gerontol. 2014. PMID: 24486129 Review.

Leboutet R, Chen Y, Legouis R, Culetto E. Leboutet R, et al. Mech Ageing Dev. 2020 Jul;189:111266. doi: 10.1016/j.mad.2020.111266. Epub 2020 May 23. Mech Ageing Dev. 2020. PMID: 32454052 Review.

Cited by

Kim Y, Pérez-González R, Miller C, Kurz M, D'Acunzo P, Goulbourne CN, Levy E. Kim Y, et al. Neurochem Res. 2022 Jul 29. doi: 10.1007/s11064-022-03701-1. Online ahead of print. Neurochem Res. 2022. PMID: 35904699

Fernandez AM, Martinez-Rachadell L, Navarrete M, Pose-Utrilla J, Davila JC, Pignatelli J, Diaz-Pacheco S, Guerra-Cantera S, Viedma-Moreno E, Palenzuela R, Ruiz de Martin Esteban S, Mostany R, Garcia-Caceres C, Tschöp M, Iglesias T, de Ceballos ML, Gutierrez A, Torres Aleman I. Fernandez AM, et al. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2204527119. doi: 10.1073/pnas.2204527119. Epub 2022 Jul 14. Proc Natl Acad Sci U S A. 2022. PMID: 35858325

Yan Y, Tang J, Yuan Q, Liu C, Chen X, Liu H, Huang J, Bao C, Hsiang T, Zheng L. Yan Y, et al. Commun Biol. 2022 Jul 14;5(1):698. doi: 10.1038/s42003-022-03666-5. Commun 专家解释究竟什么叫K线 Biol. 2022. PMID: 35835849 Free PMC article.

Naranjo-Galindo FJ, Ai R, Fang EF, Nilsen HL, SenGupta T. Naranjo-Galindo FJ, et al. Front Aging. 2022 Jun 22;3:916118. doi: 10.3389/fragi.2022.916118. eCollection 2022. Front Aging. 2022. PMID: 35821838 专家解释究竟什么叫K线 Free PMC article. Review.

Vega M, Castillo D, de Cubas L, Wang Y, Huang Y, Hidalgo E, Cabrera M. Vega M, et al. BMC Biol. 2022 Jul 12;20(1):160. doi: 10.1186/s12915-022-01352-w. BMC Biol. 2022. PMID: 35820914 Free PMC article.

热电偶测温线
双重绝缘

GG-K,TT-K,XC-K, XT-K, XL-K, XS-K, HH-K, TG-K,FF-K, PR-K系列

热电偶测温线感温线 | GG-K,TT-K,XC-K, XT-K, XL-K, XS-K, HH-K, TG-K,FF-K, PR-K系列 专家解释究竟什么叫K线
  • 高品质的K型热电偶级导线
  • 有库存 - 可立即发货
  • 可选择不同的绝缘层,线规号和长度

Star

所有金额以RMB显示
注: † 线轴和电线重量入到邻近的最大整数重量kg (lb)(不包括包装材料)。
†† 外部护套透明。
††† 如欲订购特别限制误差热电偶测温线,请将"-SLE"添加到型号中的线轴长度前。
* 护套和导体上带有分度号彩色线。
** HH热电偶测温线的正极导线上带有分度号条纹,负极导线为红色,外部护套带有分度号条纹。
*** 两股绝缘导线结合在一起,但没有外覆缠绕层。 另提供其它K型绝缘热电偶测温线。请参见熔融胶带绝缘的TFE-K和KK-K系列热电偶测温线。
订购示例:XC-K-20-SLE-1000,1000' (300 m) K型双重绝缘特别限制误差热电偶测温线

(1) 绝缘层 选项:
HH for 高温玻纤(仅20 &24线规)
GG for 玻璃
TG for PFA和玻纤
TT for Neoflon PFA(高性能)
FF for Neoflon FEP (仅20和24号线规)
PP for 聚氯乙烯(绞合只有24号) 专家解释究竟什么叫K线
PR for 聚氯乙烯撕裂线(只有24号线规)
XC for 陶瓷(仅有14 20 24号线规)
XT for 陶瓷(仅20和24号线规)
XL for 陶瓷(仅20和24号线规)
XS for 硅(仅有14 20 24号线规)

(2) 线规 选项:
20 for 20号线规
20S for 20号线规(绞合)
24 for 24号线规
24S for 24号线规(绞合)
30 for 30号线规
36 for 36号线规
40 for 40号线规

(3) 线轴线长度 选项:
25 for 25英尺
50 for 50英尺
100 for 100英尺
200 for 200英尺
500 for 500英尺
1000 for 1000英尺

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The Cowboys 专家解释究竟什么叫K线 will attempt to get off on a better foot than they did in the Mile High city for their preseason opener. After.

Cowboys-Chargers photo gallery from 2 days of joint practice

Dallas wrapped up two days of inter-squad work with the Los Angeles Chargers on Thursday. The club will get a rest day as they.